Universal healthcare coverage for first episode of schizophrenia-spectrum disorders in Chile: analysis of the administrative database.

Aim of the study was to analyse the Ministry of Health's (MINSAL) administrative database of the Universal Health Coverage (UHC) program for First Episode of Schizophrenia Spectrum Disorders (FEP-SSD). The database included every case registered in the program between 2004 and 2017. According to the timeframes established for permanence in the program, cases were defined as Suspected, FEP in diagnostic observation and FEP-SSD. Only first registers were analysed. We compared gender, age at entry, level of care and region where the case was registered. Denominator data for estimation of incidence rates were obtained from the last census. We adjusted incidence rate ratios by age, gender, and region. During the studied period, 33.207 suspected cases were registered. 27.006 (81%) were confirmed as FEP and after 6-month follow-up, 22.701 (68%) were confirmed as FEP-SSD. The median age at entry was 24 years, males entering at younger age. Male proportion was higher than female in all groups. 46.9% of all cases were detected in primary care. FEP-SSD cases were six years younger and had a higher proportion of males than discarded cases (62.6 vs 53.2%). During 169.4 million person-years at risk, crude incidence for suspected cases was 19.58 per 100.000 person-years; for FEP, 15.92 per 100.000 person-years and for FEP-SSD, 13.38 per 100.000 person-years. Chile has lower incidence of FEP-SSD compared to current world estimations but gender proportions are comparable. This UHC program has allowed early access through the integration of mental health to the health network at all levels of care.

Vigilancia epidemiológica del Traumatismo Encéfalo Craneano (TEC) en el Hospital San Bernardo de la Provincia de Salta, Argentina / Epidemiological surveillance of Cranial Brain Injury (TEC) at the San Bernardo Hospital in the Province of Salta, Argentina

Introducción: El TEC es una de las principales causas de discapacidad y muerte en nuestra sociedad. Tiene una mortalidad que ronda el 30% y una morbilidad cercana al 60%1, 2, 3, 4, 5.No hay un estudio estadístico epidemiológico exhaustivo sobre TEC en Argentina, por tal motivo la finalidad de este trabajo es conocer la epidemiología de esta patología en el Hospital San Bernardo (HSB) de Salta. Materiales y métodos: Se realizó un trabajo observacional transversal prospectivo. Se incluyeron todos aquellos pacientes que ingresaban al HSB desde agosto de 2014 hasta agosto de 2015 por el servicio de guardia con diagnóstico de TEC asociado o no a politraumatismo. Para el análisis estadístico se utilizó la versión 3.3.3. del Software R para Windows. Resultados: Se estudiaron un total de 1.496 pacientes de los cuales 76% fueron de sexo masculino y 24% femenino. El 84% de los TEC son leve, el 13% moderado y el 4% grave. Según el mecanismo del trauma, el 39% fue por accidente de tránsito, el 32% fue por agresión física y el 22% por caídas. El 19% de los pacientes fue internado. Los días promedio de internación son 10,27. De los pacientes internados, el 27% requirió cirugía de urgencia. Evaluado el GOS, el 19% tuvo GOS 1, 46% GOS 2 ­ 4 y 35% GOS 5. Conclusión: El TEC es una patología que afecta principalmente a adultos varones jóvenes. Las causas más frecuentes en nuestro medio son los accidentes de tránsito y la agresión física. El TEC en nuestro medio presenta una mortalidad global del 19%, con una morbilidad del 47%. Los datos estadísticos de nuestro Hospital referentes al TEC son concordantes con la bibliografía mundial

Introduction: Head Trauma (TBI) is one of the main causes of disability, death and economic loss in our society. It has a mortality of around 30% and a morbidity close to 60%1, 2, 3, 4, 5.There is no exhaustive statistical study on TBI in Argentina, for this reason the purpose of this project is to know the San Bernardo Hospital epidemiology of this pathology. Materials and methods: A prospective cross-sectional observational study was carried out. Patients who were admitted to the San Bernardo Hospital emergency department from August 2014 to August 2015 with a diagnosis of TBI associated or not with multiple trauma were included. Version 3.3.3 was used for statistical analysis of the R Software for Windows. Results: A total of 1.496 patients were studied, of which 76% were male and 24% female, with range of 14 ­ 97 years old (Table 4). 84% of TBI were mild, 13% moderate, and 4% severe. According to the mechanism of trauma, 39% was due to a traffic accident, 32% was due to physical aggression and 22% due to falls. 19% of the patients were hospitalized. The average days of hospitalization are 10.27. Of the hospitalized patients, 27% required emergency surgery. The patients GOS was 19% GOS 1, 46% GOS 2 ­ 4 and 35% GOS 5. Conclusion: TBI is a prevalent pathology that affects mainly young male adults. The most frequent cause in our environment are traffic accidents and physical aggression. TBI in our setting presents an overall mortality of 19% with a morbidity of 47%. Statistics of diagnosis and treatment of patients with TBI in our Hospital are similar to those published in the world bibliography and guidelines

Revisión de caso clínico desde una mirada sistémica / Clinical case review from a systemic view: clinical meeting

Paciente ELENA, 21 años. embarazo 27 semanas, separada, 4 intentos suicidas previos. Fue usuaria del programa de salud mental infantil y adulto Hospital el Pino (HEP). Hospitalizada en H. de día el año 2017. Año 2013, Alucinaciones auditivas y visuales y desajustes conductuales: Grita, rompe cosas, se pega en la cabeza. Comienza a aislarse y a faltar al colegio y atribuye sus síntomas a consumo de marihuana. Principales focos de terapia son: Disminuir situaciones de crisis y adherencia al tratamiento. Presenta mala adherencia a controles y fármacos de salud mental. Se deriva a Hospital de día. Rorschach muestra desarrollo anormal de la personalidad con rasgos histriónicos, juicio de realidad conservado y dificultad en capacidad de empatizar. Salud mental adulto: (Julio, 2015): Heridas autolíticas (cortes y rasguños), Ideas pasivas de muerte. Intervenciones desde hospital de día: Manejo de crisis, trabajar en vínculo simbiótico con madre; recibe atención por psiquiatra, terapeuta ocupacional, psicólogo y nutricionista, incluyendo intervenciones en equipo. Controles en ambulatorio (Nov 2015): Impresiona mayor conciencia de enfermedad. Abandona fármacos al sentirse mejor. Foco orientado a: Autorregulación emocional y entrenamiento cognitivo para manejo de síntomas ansiosos.

ELENA, 21 years old. Pregnancy 27 weeks, separate, 4 previous suicide attempts. She was a member of the children and mental health program Hospital el Pino (HEP). Hospitalized in Day Hospital in year 2017. 2013: Auditory and visual hallucinations and behavioral maladjustments: Screams, breaks things, hits herself in the head. She begins to isolate and to miss to the school and attributes her symptoms to consumption of marijuana. Main focuses of therapy are: To reduce crisis situations and adherence to treatment. She has poor adherence to mental health drugs and controls. She is derived to day hospital. Rorschach shows abnormal personality development with histrionic traits, a reality-preserved judgment, and difficulty in empathizing. Adult mental health: (July, 2015): Self-injuries (cuts and scratches), Passive death ideas. Interventions in day hospital: Crisis management, working in symbiotic relationship with mother; receives attention by psychiatrist, occupational therapist, psychologist and nutritionist, Including team interventions. Outpatient Control (Nov 2015): Increased awareness of illness. Abandon drugs because of feeling better. Focus oriented to: Emotional self-regulation and cognitive training for the management of anxious symptoms.

The effect of a mindfulness-based intervention in cognitive functions and psychological well-being applied as an early intervention in schizophrenia and high-risk mental state in a Chilean sample: study protocol for a randomized controlled trial.

BACKGROUND: According to the projections of the World Health Organization, 15% of all disabilities will be associated with mental illnesses by 2020. One of the mental disorders with the largest social impacts due to high personal and family costs is psychosis. Among the most effective psychological approaches to treat schizophrenia and other psychotic disorders at the world level is cognitive behavioral therapy. Recently, cognitive behavioral therapy has introduced several tools and strategies that promote psychological processes based on acceptance and mindfulness. A large number of studies support the effectiveness of mindfulness in dealing with various mental health problems, including psychosis. This study is aimed at determining the efficiency of a mindfulness-based program in increasing cognitive function and psychological well-being in patients with a first episode of schizophrenia and a high risk mental state (those at risk of developing an episode of psychosis). METHODS AND DESIGN: This is an experimentally designed, multi-center randomized controlled trial, with a 3-month follow-up period. The study participants will be 48 patients diagnosed with schizophrenia (first episode) and 48 with a high-risk mental state, from Santiago, Chile, aged between 15 and 35 years. Participants will be submitted to a mindfulness-based intervention (MBI), which will involve taking part in eight mindfulness workshops adapted for people with psychosis. Workshops will last approximately 1.5 hours and take place once a week, over 8 weeks. The primary outcome will be the cognitive function through Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) and the secondary outcome will be psychological well-being measured by self-reporting questionnaires. DISCUSSION: The outcomes of this trial will add empirical evidence to the benefits and feasibility of MBIs for the psychotherapeutic treatment of patients with schizophrenia and high-risk mental states in reducing cognitive impairment in attention, working memory, and social cognition, as well as increasing the psychological well-being by empowering the patients' personal resources in the management of their own symptoms and psychotic experiences. TRIAL REGISTRATION: ISRCTN registration number ISRCTN24327446 . Registered on 12 September 2016.

Malformaciones cavernosas supratentoriales en una institución argentina: experiencia del tratamiento quirúrgico / Supratentorial cavernous malformations in an Argentinian institution: experience with surgical treatment

Introducción. Las malformaciones cavernosas son lesiones vasculares del sistema nervioso central constituidas por endotelio sinusoidal que forma capilares agrupados o cavernas que carecen de los elementos típicos de una pared arterial madura y ausencia de tejido neural interpuesto. El endotelio está rodeado por una densa capa de fibras colágenas que dejan pequeñas hendiduras por las que se extravasa hemosiderina. Se comunican con el sistema vascular a muy baja presión y su tratamiento puede ser por microcirugía o radiocirugía. Objetivos. Analizar las malformaciones cavernosas supratentoriales tratadas quirúrgicamente en nuestra institución (FLENI), determinar la epidemiología y las características intrínsecas, estudiar la clínica de presentación, determinar las indicaciones quirúrgicas y complicaciones, y establecer el pronóstico. Pacientes y métodos. Estudio retrospectivo analítico de historias clínicas e imágenes de pacientes operados de malformaciones cavernosas supratentoriales en la FLENI desde enero de 1996 hasta diciembre de 2013. Resultados. Evaluamos a 51 pacientes, de 34 años de media, seguidos durante una media de 30 meses. El 1,96% de los pacientes presentó diagnóstico incidental y el resto mostró síntomas. El 23,52% presentó hemorragia en el momento del diagnóstico. En todas las cirugías se logró una exéresis total de las malformaciones cavernosas supratentoriales. Se observó un caso de meningitis postoperatoria. Conclusiones. La tasa de sangrado de las malformaciones cavernosas supratentoriales en nuestro medio es del 1,38% por paciente por año. El tratamiento quirúrgico es eficaz para erradicar o disminuir los síntomas y para evitar un posible resangrado. Presenta una tasa muy baja de complicaciones y un pronóstico neurológico favorable (AU)

Introduction. Cavernous malformations are vascular malformations of the central nervous system formed by a group of capillaries not covered by pia mater and communicated to the vascular system at very low pressure with very slow flow. Surgery or radiosurgery are the treatment modalities. Aims. To analyze our results after surgical treatment of supratentorial cavernous malformations, reviewing clinical presentation, surgical indications and postoperative complications. Patients and methods. Analytical retrospective study of medical records and images of patients who underwent resection of supratentorial cavernomas at FLENI from January 1996 until December 2013. Results. We evaluated 51 patients, mean age 34 years, followed for an average of 30 months. In 1.96% of patients diagnosis was incidental, the rest all presented symptoms. Bleeding at diagnosis was observed in 23.52%. Total excision of supratentorial cavernous malformations was possible in all cases. The only postoperative complication was one case of meningitis. Conclusions. The bleeding rate of supratentorial cavernous malformations in our series was 1.38% per patient per year. Surgical treatment effectively eliminated, or at least reduced symptoms, prevented rebleeding, and decreased need for antiepileptic drug therapy. Surgery have a low complication rate and good outcome (AU)

[Cervical aspergillosis with dissemination to the central nervous system: Case reports and review of the literature]. / Aspergilosis cervical con diseminación al sistema nervioso central. Presentación de un caso y revisión de bibliografía.

BACKGROUND: Invasive aspergillosis (IA) of the central nervous system (CNS) is an uncommon condition that usually occurs in immunocompromised patients. This illness can manifest as meningitis, or as a micotic aneurism, stroke or abscess. The infection affects the CNS either primarily or, more often, secondarily via blood dissemination from a distant focus, and has a poor prognosis. We present a patient with IA primarily affecting the cervical bones, with later spread into the brain. CASE DESCRIPTION: A 25-year old male was receiving chemotherapy for acute lymphocytic leukemia when he developed pneumonitis secondary to methotrexate and was started on corticosteroids. He subsequently developed cervicalgia, prompting a needle biopsy of the fourth vertebrae, after which a diagnosis of osteomyelitis was made. Even though the biopsy culture was negative, empirical antibiotics were initiated. A parietal lobe lesion was treated surgically months later after the patient presented with three episodes of transient aphasia. After A. fumigatus grew in culture, the patient's antibiotic regimen was changed to treat the specific agent with a good response. CONCLUSION: IA must be considered a possibility whenever an immunocompromised patient presents with a new brain lesion. These lesions require surgical evacuation, a procedure that allows for diagnostic confirmation and enhances prognosis. Appropriate anti-fungal therapy must be started as soon as the diagnosis is confirmed. In addition, the patient's neurological exam must be repeated and images obtained periodically to monitor treatment and detect possible recurrences.

Aspergilosis cervical con diseminación al sistema nervioso central. Presentación de caso y revisión de bibliografía / Cervical aspergillosis with dissemination to the central nervous system. Case presentation and bibliography review

INTRODUCCIÓN: la Aspergilosis Invasiva (AI) del Sistema Nervioso Central (SNC) es infrecuente y ocurre generalmente en pacientes inmunocomprometidos. Puede presentarse con cuadros de meningitis, aneurismas micóticos, infartos o abscesos. Es una infección con pronóstico reservado y puede afectar el SNC de forma primaria o secundaria a partir de un foco que se disemina por vía hematógena. Presentamos el caso de un paciente con AI con invasión primaria a nivel óseo y diseminación posterior al cerebro. CASO CLÍNICO: paciente masculino de 25 años con diagnóstico de leucemia linfática aguda en tratamiento quimioterápico que presentó neumonitis por metotrexate por lo que inicia tratamiento con corticoides. Posteriormente agregó cervicalgia y con el diagnóstico de osteomielitis cervical se realiza punción bajo tomografía computada (TC) sin aislarse gérmenes. Se colocó Halo Vest e inició tratamiento antibiótico empírico. Posteriormente presentó afasia de expresión secundaria a lesión frontal izquierda. Se realizó evacuación de absceso cerebral aislando A. fumigatus. El tratamiento antibiótico específico posterior permitió una buena respuesta clínica y radiológica. CONCLUSIÓN: la presencia de lesiones en el SNC de pacientes inmunocomprometidos debe incluir a las micosis como diagnóstico diferencial. La evacuación quirúrgica permite llegar rápidamente al diagnóstico mejorando la respuesta posterior al tratamiento antibiótico. Para evaluar la respuesta terapéutica y posibles recaídas se debe realizar un seguimiento periódico clínico radiológico

INTRODUCTION: invasive aspergillosis (IA) of the central nervous system (CNS) is an uncommon condition that usually occurs in immunocompromised patients. This illness can manifest as meningitis, or as a micotic aneurism, stroke or abscess. The infection affects the CNS either primarily or, more often, secondarily via blood dissemination from a distant focus, and has a poor prognosis. We present a patient with IA primarily affecting the cervical bones, with later spread into the brain. CASE REPORT: a 25-year old male was receiving chemotherapy for acute lymphocytic leukemia when he developed pneumonitis secondary to methotrexate and was started on corticosteroids. He subsequently developed cervicalgia, prompting a needle biopsy of the fourth vertebrae, after which a diagnosis of osteomyelitis was made. Even though the biopsy culture was negative, empirical antibiotics were initiated. A parietal lobe lesion was treated surgically months later after the patient presented with three episodes of transient aphasia. After A. fumigatus grew in culture, the patient's antibiotic regimen was changed to treat the specific agent with a good response. CONCLUSION: IA must be considered a possibility whenever an immunocompromised patient presents with a new brain lesion. These lesions require surgical evacuation, a procedure that allows for diagnostic confirmation and enhances prognosis. Appropriate anti-fungal therapy must be started as soon as the diagnosis is confirmed. In addition, the patient's neurological exam must be repeated and images obtained periodically to monitor treatment and detect possible recurrences

Hidrocefalia externa del adulto: manejo terapéutico y diagnóstico diferencial conhematoma subdural crónico e higroma subdural. Presentación de un caso y revisión de la literatura / Adult external hydrocephalus- therapeutical measures & differential diagnosis with chronic subdural hematoma & subdural higroma: case report & literature review

Objetivo: presentar un caso de hidrocefalia externa en un adulto. Presentación: paciente de 73 años con trastornos en la marcha y paresia braquial derecha de tres semanas de evolución secundarios a hematoma subdural (HSD) frontotemporoparietal izquierdo. Intervención: tras doble evacuación y craniectomía descompresiva por resangrado en postoperatorio inmediato, evolucionó con sensorio fluctuante y confuso, evidenciando en tomografías computadas (TAC) controles colecciones líquidas bilaterales extraaxialescon ventrículos, surcos y cisternas conservados, “signo de venas corticales” a través de cada colección con herniación de ésta a través de la craniectomía. Por punción transcutánea a través de ella se mide la presión del espacio subdural de 26 cm de H2O apoyando el diagnóstico de HEA. Se coloca drenaje subduroperitoneal bilateral logrando una evolución favorable. Conclusión: el manejo terapéutico óptimo de las colecciones subdurales aún no ha sido establecido. La conducta conservadora resulta adecuada en casos asintomáticos y sin efecto de masa mientras que en efusiones subdurales bastaría irrigar la cavidad o una derivación subduroperitoneal. Las derivaciones de LCR resultan de impredecible eficacia en HEA y las colecciones asociadas persisten o recidivan tras su evacuación, por lo que una correcta selección de pacientes es clave antes de cualquier decisión terapéutica.

Neurocitoma extraventricular atípico con siembra por trayecto de biopsia y diseminación leptomeníngea craneoespinal: reporte de primer caso y revisión de la literatura / Atipical extraventricular neurocytoma with needle tract seeding and craniospinal dissemination: case report and literature review

Objetivo: reportar el primer caso de EVN atípico con siembra neoplásica por trayecto de biopsia y diseminación craneoespinal. Descripción: paciente de 19 años con debilidad y parestesias en hemicuerpo derecho de dos meses de evolución evidenciando en resonancia magnética (IRM) tumor talámico izquierdo sin realce tras el contraste. Intervención: la biopsia esterotáctica revela un tumor redondo-celular compatible con oligodendroglioma. Se indica radioterapia y quimioterapia. Al tercer mes presenta hidrocefalia por progresión tumoral. Se coloca shunt de LCR. Al año se intensifica el síndrome talámico, presenta trastornos oculomotores y esfinterianos. IRM evidencia compromiso leptomeníngeo difuso con implantes nodulares espinales, en tronco encefálico y a nivel de abordaje estereotáctico frontal izquierdo compatible con siembra por trayecto de biopsia. Craneotomía centrada en trepanación previa permite resecar tejido neoplásico reinterpretado anatomopatológicamente como EVN atípico diseminado con Ki67>30%. Conclusión: los oligodendrogliomas representan el principal diagnóstico diferencial imagenológico y anatomopatológico de EVN. Se presume su origen en células precursoras biopotenciales de matriz germinal periventricular con capacidad de diferenciación glial y neuronal que explicaría su capacidad excepcional para la diseminación leptomeníngea. El Ki67 es el principal factor pronóstico evolutivo en neurocitomas. Aquellos con Ki67>2% (atípicos) requieren monitoreo estricto por mayor riesgo de recurrencia y diseminación.

Device-associated infection rate and mortality in intensive care units of 9 Colombian hospitals: findings of the International Nosocomial Infection Control Consortium.

OBJECTIVE: To perform active targeted prospective surveillance to measure device-associated infection (DAI) rates, attributable mortality due to DAI, and the microbiological and antibiotic resistance profiles of infecting pathogens at 10 intensive care units (ICUs) in 9 hospitals in Colombia, all of which are members of the International Infection Control Consortium. METHODS: We conducted prospective surveillance of healthcare-associated infection in 9 hospitals by using the definitions of the US Centers for Disease Control and Prevention National Nosocomial Surveillance System (NNIS). DAI rates were calculated as the number of infections per 100 ICU patients and per 1,000 device-days. RESULTS: During the 3-year study, 2,172 patients hospitalized in an ICU for an aggregate duration of 14,603 days acquired 266 DAIs, for an overall DAI rate of 12.2%, or 18.2 DAIs per 1,000 patient-days. Central venous catheter (CVC)-related bloodstream infection (BSI) (47.4% of DAIs; 11.3 cases per 1,000 catheter-days) was the most common DAI, followed by ventilator-associated pneumonia (VAP) (32.3% of DAIs; 10.0 cases per 1,000 ventilator-days) and catheter-associated urinary tract infection (CAUTI) (20.3% of DAIs; 4.3 cases per 1,000 catheter-days). Overall, 65.4% of all Staphylococcus aureus infections were caused by methicillin-resistant strains; 40.0% of Enterobacteriaceae isolates were resistant to ceftriaxone and 28.3% were resistant to ceftazidime; and 40.0% of Pseudomonas aeruginosa isolates were resistant to fluoroquinolones, 50.0% were resistant to ceftazidime, 33.3% were resistant to piperacillin-tazobactam, and 19.0% were resistant to imipenem. The crude unadjusted attributable mortality was 16.9% among patients with VAP (relative risk [RR], 1.93; 95% confidence interval [CI], 1.24-3.00; P=.002); 18.5 among those with CVC-associated BSI (RR, 2.02; 95% CI, 1.42-2.87; P<.001); and 10.5% among those with CAUTI (RR, 1.58; 95% CI, 0.78-3.18; P=.19). CONCLUSION: The rates of DAI in the Colombian ICUs were lower than those published in some reports from other Latin American countries and were higher than those reported in US ICUs by the NNIS. These data show the need for more-effective infection control interventions in Colombia.

Coexistencia de problemas nutricionales en niños de 6 a 9 años de edad, de centros educativos estatales de Matucana, Santa Eulalia y Lima / Coexistence of nutritional problems in 6 to 9 year-old students at, Matucana, Santa Eulalia and Lima state educactional centers

Objetivo: Conocer la coexistencia de problemas nutricionales en niños de 6 a 9 años de edad de centros educativos estatales. Material y Métodos: Se estudió 241 niños de Matucana, Santa Eulalia y Lima. Para el diagnóstico nutricional se usó el índice de masa corporal (IMC) con la clasificación de Must y col. con los siguientes criterios diagnósticos, menor de 5, entre 5 y 15, 15 a 85, 85 a 95 y mayor del 95 percentil, para definir el déficit, bajo peso, normal, sobrepeso y obesidad respectivamente. La desnutrición crónica fue determinada usando el National Center for Health Statistics (NCSH) y el menor de menos dos desvío estandar. Se dosó hemoglobina en sangre y como criterio diagnóstico la menor de 12 g/dL, agregándole 0,4 g/dL por cada 1000 msnm. Resultados: El 22,4, 14,1, 10,0, y 69,3 por ciento de los niños presentan desnutrición crónica, sobrepeso, obesidad y anemia nutricional, respectivamente. De los que tienen desnutrición crónica, 11,1, 9,3 y 66,7 por ciento están con sobrepeso, obesidad y anemia; y de los anémicos, 16,8 y 12,6 por ciento se encuentran con sobrepeso y obesidad. Existe un 2,1 por ciento de niños con desnutrición crónica, sobrepeso y anemia y un porcentaje similar con desnutrición crónica, obesidad y anemia. Conclusión: La presencia de dos e incluso tres enfermedades nutricionales en un mismo niño amerita implementar políticas cuyas estrategias contemplen esta posibilidad.

Perfil geotermometrico entre Juan Bautista Alberdi y Villa de Rio Hondo (Provincias de Tucuman y Santiago del Estero, Argentina)

Este trabajo consituye una sintesis de un informe inedito de Vergara (1997) que realizaron un censo de recursos hidricos subterraneos con anomalias geotermales en el sector austral de la provincia de Tucuman y occidental de la provincia de Santiago del Estero. Asi se concreto la realizacion de un perfil geotermometrico E-O entre las localidades de Juan Bautista Alberdi (Tucuman) y Villa Rio Hondo (Santiago del Estero)